Does CYP1A2 genotype change how caffeine affects performance? A 2023 meta-analysis linked the CC genotype to worse performance, but not after excluding studies with reported conflicts of interest
Oct 27
3 min read
Some people swear caffeine makes them faster and stronger; others feel nothing, or feel worse. A popular explanation is genetics, particularly the CYP1A2 gene that governs how quickly caffeine is cleared, and the ADORA2A gene for the adenosine receptor caffeine blocks. Direct-to-consumer tests now sell this as personalised supplement advice. Here is what the trials and the newest meta-analysis actually show.
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