Leptin and Myostatin: The Body's Two Brakes - One on Appetite, One on Muscle, and Why Neither Is the Shortcut It Sounds Like

Two hormones act as the body's brakes on the things athletes most want to change: leptin restrains appetite in proportion to how much fat you carry, and myostatin restrains muscle growth. Both have inspired the same dream - inject the appetite hormone to stop eating, block the muscle brake to grow - and both dreams have run into the same wall. The biology is real and elegant, but the body defends its set points, and the shortcuts do not work the way the headlines promise.

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